Protection of acute renal injury in severe experimental acute pancreatitis

Experimental model of severe acute pancreatitis in rabbits.

PURPOSE To develop an experimental model of severe acute pancreatitis in rabbits through a pancreatic ductal injection of sodium taurocholate. METHODS Twenty-four albino rabbits of the New Zealand lineage were distributed into four groups of six animals (A, B, C and S). The rabbits of three experimental groups (A, B and C) were submitted to a laparatomy and received a pancreatic ductal inject...

Inhibition of cyclooxygenase-2 in experimental severe acute pancreatitis.

BACKGROUND The standard treatment for acute pancreatitis (AP) is still based on supportive care. The search for a new drug that could change the natural history of the disease is a continuing challenge for many researchers. The aim of this study is to evaluate the effect of a cyclooxygenase-2 (COX-2) inhibitor on experimental AP in rats. METHODS The animals were divided into 2 groups: Group 1...

Severe acute pancreatitis

Pancreatitis is an inflammatory disorder of the pancreas which occurs with an estimated incidence of 10–40 per 100 000 per year in the UK. Mild acute (oedematous or interstitial) pancreatitis accounts for 80% of cases, is self-limiting, and usually resolves with simple supportive management in 3–5 days. Severe acute pancreatitis (SAP) accounts for the remainder of cases and was defined by the A...

Severe Acute Pancreatitis

Methods Between April 22, 1990 and April 19, 1993, 102 patients with severe acute pancreatitis were admitted to 16 participating hospitals. Patients were entered into the study if severe acute pancreatitis was indicated, on admission, by multiple laboratory criteria (Imrie score 2 3) and/or computed tomography criteria (Balthazar grade D or E). Patients were randomly assigned to receive standar...

Severe acute pancreatitis.